
The Health Systems Impact Modelling project
This community of practice emerges from a larger programme of work supported by the Alliance for Health Policy and Systems Research at WHO, with funding from The Gates Foundation. Read more
Website: https://www.imperial.ac.uk/jameel-institute/
Focus: Epidemiology, mathematical modelling of infectious diseases, environmental health, health economics
Key activities:
- COVID-19 pandemic modelling that influenced UK and US government policies
- DAEDALUS integrated economic-epidemiological model for optimizing economic sectors during health emergencies
- Kenneth C. Griffin Initiative for the Economics of Pandemic Preparedness
- Research areas: Strengthening health systems, responding to health emergencies, building partnerships and capacity
Website: https://chds.hsph.harvard.edu/
Focus: Decision science methods applied to health policy and medical practice
Key activities:
- Teaching core decision science courses (decision analysis, cost-effectiveness analysis)
- Health Systems Innovation Lab for comparative health systems research
- Research on health disparities, medical impoverishment, financial risk protection
Website: https://www.idmod.org/
Focus: Mathematical modelling of infectious diseases and health systems to support global health improvements
Key activities:
- Quantitative methodologies for maternal/child health, health delivery strategies, and health system effectiveness
- Transmission dynamics modelling for malaria, measles, polio, TB, HIV, pneumonia, typhoid, COVID-19
- Development of open-source modelling tools shared as global public goods
- Data-driven approaches including dynamic models, statistical analysis, and innovative algorithms
- Development of open-source modelling tools shared as global public goods
- Data-driven approaches including dynamic models, statistical analysis, and innovative algorithms
Website: https://www.healthdata.org/
Focus: Population health research with comprehensive measurement of global health problems
Key activities:
- Global Burden of Disease (GBD) Study – comprehensive mortality and disability data across countries
- COVID-19 pandemic modelling that informed US government guidelines
- Global Health Data Exchange (GHDx) platform for health datasets
Website: https://iiasa.ac.at/
Focus: Applied systems analysis for global problems
Key activities:
- GAINS model for air quality and health impacts
- Population and demographic modelling
- Food and land use systems (FABLE Consortium)
- Integrated assessment of climate-health interactions
Website: https://hbhi.jhu.edu/initiatives/chspm
Focus: U.S. health care system analysis using predictive models and causal inference
Key activities:
- To become a definitive source of information on health sector policy levers
Website: https://www.lshtm.ac.uk/
Key activities:
- Centre for Mathematical Modelling of Infectious Diseases (CMMID) – 150+ researchers in epidemiology, mathematics, economics, statistics
- Health Systems and Policy Unit – Macro-economic modelling of health and health policy
- Environment and Health Modelling Lab – Statistical methods for climate-health interactions
- Notable projects: COSMIC project using system dynamics for health programme evaluation
Website: https://mitsloan.mit.edu/centers-initiatives/health-systems-initiative
Focus: Healthcare operations research and analytics
Key activities:
- Healthcare Operations – hospital optimization, supply chains, transportation
- Healthcare Analytics – machine learning tools for diagnostics and decision support
- Healthcare Incentives – economic models for healthcare delivery
Website: https://www.path.org/
Focus: Global health systems strengthening through evaluation and implementation
Key activities:
- Global Fund Prospective Country Evaluation (with IHME) in 8 countries
- Mixed-methods evaluation combining qualitative process evaluation with quantitative impact analysis
- Africa Health R&D Commitments Tracker for investment transparency
- Findings: 37% of Global Fund Round 8 allocated to health systems strengthening
Website: https://www.swisstph.ch
Focus: Systems innovation research
Key activities:
- Strengthening mortality systems to inform health policy
- WHO Collaborating Center for Verbal Autopsy
- Health sector response to violence against women and girls (VAWG)
- Computational modeling of cardiovascular risk interventions simulator, São Paulo, Brazil
Website: https://thanzi.org/
Focus: Health systems modelling and health economics in African regions
Key activities:
- Evidence generation for locally relevant health systems research
- Capability building in health economics and health system modelling
- Direct engagement with Ministry of Health and Finance planning departments
- Research led by local and regional demand across East, Central, Southern and West Africa
Website: https://www.ndm.ox.ac.uk/
Focus: Training mathematical modellers for global health decision-making
Key activities:
- Mathematical and economic modelling
- Scientific programming and bioinformatics
- Global health financing
- Spatial analysis and model fitting
- Research areas: Infectious diseases, cancer, immunology, vaccinology
Focus: Mathematical simulation models for health and financial outcomes of public health policies
Key activities:
- Center for Infectious Disease Modeling and Analytics (CIDMA)
- Quantitative evaluation of vaccination strategies and health interventions